Good research should be well planned, aptly designed, and ethically approved. Make sure that laboratory and clinical research is driven by a defined protocol, which is agreed by all contributors and collaborators. For studies involving individuals, patient medical records, and anonymised human tissues, always obtain a formal ethical approval from research ethics committee. It is advisable that full informed consent is obtained from participants or research ethics committee. Similarly, animal experiments should comply with ethical and regulatory principles, and licensing arrangements. Intellectual honesty should always be practiced in medical and scientific studies and misconduct must be avoided. Committee on Publication Ethics or COPE guidelines is a one stop solution which will help you gain a fair idea on ethical approval procedures.