Cancer’s ability to elude the immune system is a well-known characteristic. While much research has focused on somatic mutations within cancer cells that enable this evasion, little attention has been given to somatic mutations in tumor-infiltrating immune (TII) cells. These mutations do not directly fuel tumor growth but may indirectly support it by hindering an effective anti-tumor immune response. In essence, investigating these mutations in TII cells could provide valuable insights into how cancers manage to evade our immune defenses.
Related Posts
cGAS-STING Saga: Navigating the Intricacies of Cardiovascular Resilience
The cyclic cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGAS)-stimulator of interferon genes (STING) pathway is important in innate immune response and has been linked to cardiovascular inflammation, remodeling, and degeneration. Cardiovascular diseases (CVDs) are a leading cause of death worldwide. Inflammation is a key factor in the development and progression of CVDs. The […]
Beyond the Brewery: Diastatic Yeasts’ Evolutionary Escape into the Wild
In an 18-month study of a Portuguese craft brewery, diastatic yeast contaminations were traced to environmental strains, distinct from the production yeast. Such contaminations, often unnoticed, were detected due to a specific PCR protocol. These contaminants, linked genetically to strains in Botswana, reveal the widespread and ecological presence of diastatic yeasts. Unlike Beer 1 strains, […]
Your Immune Cells Hold the Key to Predicting Flu Outbreaks
Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory infection in humans and animals worldwide. Upon detection of IAV infection, host immune system aims to defend against and clear the viral infection. Innate immune system is comprised of physical barriers (mucus and collectins), various phagocytic cells, group of cytokines, interferons (IFNs), and IFN-stimulated […]