A novel approach of gene therapy

Exosomes to amend disease processes: Researchers have established a novel gene therapy method by converting human cells into bulk creators of mini-sized nano-particles poised of hereditary material that has the capability to alter disease progressions. The technique uses exosomes; that are bio-friendly transporters of beneficial ingredients that make a way for cells to connect with other cells. This technique depends on patented skill that stimulates contributed adult stem cells to produce millions of exosomes that work as nanocarriers comprising a drug. When these exosomes are inserted into the blood, they are well aware of where to target, even though it is the brain. These exosomes collected from adult human cells, functions as nano-carriers containing a drug.

Application of tissue Nano transfection : In 2017, James Lee, professor emeritus and colleagues at the Ohio State University made impressions with news broadcast of tissue nano transfection (TNT); a regenerative medicine discovery. This technique is based on a nanotechnology-based piece to transport biological load straight into the skin, and changes adult cells into the desired cells. This was also adapted by Zhaogang Yang, a postdoctoral researcher at the University of Texas Southwestern Medical Center, termed cellular nanoporation.

The reason exosomes are designated to avert diseases: In in-vitro conditions, the artificial DNA force-fed to giver cells is imitated into a different fragment containing messenger RNA that holds the commands required to yield a definite protein. Every exosome foam comprising messenger RNA is converted into a nanoparticle prepared for transference, with no blood-brain barrier to worry about. Lee said, “We don’t want the exosomes to go to the wrong place. They’re programmed not only to kill cancer cells but to know where to go to find the cancer cells. You don’t want to kill the good guys.”

Light of Hope in the therapy: The best part for this is that they exosomes do pass the blood-brain barrier; maximum drugs can’t. An additional benefit that it occurs is zero toxicity; they do not induce an immune response. This drug-delivery method has the potential for the imminent uses in neurological ailments such as Alzheimer’s and Parkinson’s disease. Expectantly, someday this can probably be used to treat the deadly diseases.

Making a Firm Decision: “Traditional vs. Open Access Journals”

We all know that making good choices in terms of academics and scientific career is the key to success. Research writing and publications compliment the career of a scientist or an academician. Moreover, publications in reputed (high impact factor) and peer-reviewed journals produces global recognition to their contribution towards the scientific community.

Selecting an appropriate journal to publish your invaluable contribution is the major step in disseminating your research findings. The research ought to be published in the right journal for reaching the target audience with desired impact. However, many researchers struggle to make the right choice while selecting a journal as they get confused between Open access and Traditional Journals. The decision also becomes difficult while considering the journal’s performance (range and impact on audience), cost of publication (Submission charges and Article processing charges) and duration of publication process.

Traditional Journal vs. Open Access Journals: Based on the different factors

Traditional Journals

Traditional journals are those which generally do not levy any fee on authors or contributors for scientific publication. These journals are funded by subscriptions and advertisements and hence, the readers are charged for accessing or downloading any content in the journal.

The comparison between the traditional and open access journals suggests that the traditional journals possess higher reputation as they are not new to the experts in the field and association with reputed institutions and medical centres. However, higher reputation does not mean that it will reach broader audience. Because of high subscription charges for the readers, the content remains exclusive for specific mass and this is also the reason for not receiving desired number of citations after the introduction of Open Access journals.

The traditional journal charges per page for the printed versions which may vary based on the number of colour figures. However, for read only service the readers need to subscribe to the journal with subscription charges ranging from $100 per individual to $50,000 for institutions.

The traditional journal generally takes around 4-6 months for the quality checking and peer review process. The delay in the process is because of the number of articles received and their pending physical printings and distributions.

Open Access

“Open Access” is the idea and practice that created a movement which enabled the journals to provide complete barrier-free and cost-free access to the readers. Providing free access means that the readers can read, download, copy (with prior acknowledgement), share and print the online information available in form of articles.

Based on the different factors for making the appropriate choice, open access is changing the landscape of the research industry and has returned scholarly publishing to its original purpose of “spreading knowledge without any barrier”.

Publishing in open access journals provides greater visibility as it reaches broader audience without any fee. However, as no publication is without any fee, the author is responsible to pay the Submission charges and Article processing charges. Generally, the fees range between $50-$5000 based on the impact and reputation of the journals.

Most of the researchers opt for open access as they may not be popular in their field as, open access circulates the articles to a wider audience using different platforms to reach different researchers in the field worldwide. That is why, most of the traditional journals have now adopted the “Open Access Policy” either completely (full open access) or partially (hybrid open access).

Scientific publication represents the reputation of the researcher and hence the faster you publish the greater is the competitive edge they receive over other competitors. Most importantly, the researcher who gets published first receives the credit for the idea and the manuscript. Open access journals significantly reduce the time of publication with rapid peer review process. However, some researchers doubt the quality of the process and also consider this process as fake.

Role of ManuscriptEdit in helping you to make the correct choice

You might have now understood the pros and cons of each type of journals, but you still might not be completely sure about your choice.

The selection of the journal (whether open access or traditional) should be based on one’s requirement and hence, ManuscriptEdit provides a “Journal Selection Report” service which is prepared by considering the quality, scope and novelty of the manuscript. However, the author can also share their recommendations on the basis of different criteria such as the impact factor, reputation, indexing and cost which needs to be covered. We understand the effort that has been put to produce a quality research paper and hence, we guide the authors to make the right selection for getting the article published in desired journal.

Copyright Myths vs. Facts

The objective of copyright law is to provide a legal framework to assure creators of original work that their artistic talent is fairly rewarded and protected.

The advancement in technology and the Internet has made it much easier for works to be created, published, and copied as well. With increasing digital content, there are many misconceptions regarding the copyright law circulating online. This is an attempt to clarify the myths and facts associated with copyright law.

Copyright covers a wide range of creations that include literary works, artistic works, development software, computer programs, movies, music, etc. There is a myth that one can copy or republish a particular content as long as credit is given to the original owner. But the fact is that the exclusive right to copy content belongs to the owner of the copyright only and no one is entitled to reuse a work in any way unless an explicit permission is obtained from the owner.

It is also assumed that content published online becomes public property as it is in the public domain and it diminishes copyright protection on it. But the fact is that the authors have exclusive right on the published content, so other users should take measures to confirm ownership of the content before publication.

There is a third misconception that any work that doesn’t bear the copyright notice or tag is open to be reused. However, copyright exists in a work from the moment the content is recorded in any fixed and observable form. Non-display of the copyright note does not confer any permission on anyone to reuse that work.

Another area of uncertainty is regarding derivative works. The fact is that such works are still covered by copyright. It is believed that if one modifies or partly uses someone else’s work, it doesn’t breach the copyright law. On the contrary, it is only treated as a ‘fair use’ when a person accesses the work just as a reference.

There is another gray area related to the financial gain from the protected content. It is presumed that a person can use another person’s work if there is no financial gain or profit from it. But in reality, copying someone else’s work is a breach of copyright law, and money is not a consideration in that case.

Many myths persist about fair use, which is an essential right that allows the use of copyrighted material under certain circumstances. Therefore, while creating, sharing, and consuming media on the Internet may be easier than ever before, copyright regulations are still in force and must be respected.

Funding your Research: A Far-reaching Aspect

In a research scholar’s career, the main hurdle to his/her accomplishment is the lack of grants for his/her research. At times, the scholars spend sleepless nights worrying about finding funding resources for their research studies.

Testing or developing theories calls for an in-depth research, with that comes huge funding needs. Hence, here are some of the suggestions that will surely mitigate the funding burden on the research scholars and help them to focus more on their research findings.

Suitable funding resources

National Institutes of Health (NIH): It is the largest public funding organisation for biomedical research in the world, which invests billions of dollars every year with an aim to enhance life, and reduce illness and disability through frequent innovative researches. NIH has funded varied studies that proved as breakthroughs in treatment and prevention, and helping people sustain longer, lead healthy life, and building a foundation for discoveries.

Grants.Gov: It is considered as one of the largest funding sources for research works in the USA.

National Science Foundation (NSF): It is a funding resource for scientists and researchers desiring federal grants for their research studies. NSF has gained fame in providing financial support to academic institutions for basic research and experiments. It has surpassed the margin marked by NIH.

Newton’s List: It is one of the globally available resources providing grants for basic experiments and research works in agricultural sciences, engineering, natural sciences, social sciences, or technology.

Terra Viva Grants Directory: It is a better option of funding resource with both information and opportunities for researchers seeking project grants for fields like agriculture, energy, environment, and natural resources.

Office of Extramural Research (OER) at NIH: It is one of the biggest sources of research grants in category of scientific research across the word. They do not restrict their assistance to funding only, instead they also guide the researcher with their leadership skills, oversight view, and tools required in administering and managing the NIH grants policies and operations.

The Spencer Foundation: It is the best place to approach for funding scientists and researchers who are initiating their studies on a low scale based only on the novelty of the research work.

Universities or Institutes: If you are affiliated with the University, You can directly visit your university office or the department head. Many recognized universities have offices that deal with sponsored programs. They can coordinate your request for grants and helps you unearth the various opportunities available with them.

Fiscal sponsorship: You can also enquire about the funding sources from your colleagues or peers. They can help you find out certain non-profit organization who shares your research interest. In this case, you might get hold of more grant opportunities.

Usage of machine translation software in academic writing

The number of research articles submitted by non-native English speaking authors is increasing rapidly. However, the language barrier and time constraints are hindering their publication in English journals. With an intention to expand the reach of such innovative researches to other scholars and researchers, automated or machine translation software is a trending tool among academicians.

Akin to online proofreading software, the machine translation system is readily available on the web at little or no fee. Software such as Google Translate, Bing Translator, and Babel Fish are widely used in translating content through the rules-based systems. These systems are based on the translation techniques that analyze word patterns in the text in the documents that have been previously published or translated.

Cons of machine translation

Though useful to some extent, machine translation causes several errors in the document, thus affecting comprehension. Some serious mistakes recorded till date include:

  • Unnecessary fragments of the sentences in the translated material
  • Redundant and lengthy sentences creating confusion
  • Phrases ordered in an illogical manner
  • Word-by-word translation instead of contextual translation

The poor sentence structure along with errors in syntax and terminologies result in lack of clarity in the content and affect readability and comprehension. Eventually, the translated manuscripts or articles get rejected by journal editors because of a lack of clarity and coherence.

Machine translation software vs. Human Translators

Automated translation systems have been used for several years with the aforementioned drawbacks. Hence, the idea of utilizing machine translation software, i.e., Google Translate, Bing Translator, and Babel Fish, etc., is a risky one. Conversely, it is more advisable to use the expertise of academic translators to maintain or even enhance the integrity of the research material. Even if more expensive, manual translation services are worth it because they add credence to your manuscript.

Proper Citation: A Key Norm in Academic Publishing

What to Cite?
Academic publishing is important for the career enhancement of every researcher. A long string of publications under the belt of a researcher not only performs the constructive role of filling gaps in existing research, but also enhances the chances of the researcher being cited by other researchers. The number of times your research work is cited indicates the impact of the study in your research field.
Researchers usually draft their own investigations in the light of discoveries of other researches. In the process, it is vital for these study findings to be recognized as standalone researches by maintaining a strategic distance from issues like copyright infringements and plagiarism. To walk this academic tightrope, researchers take care to refer to previous studies by presenting the thoughts of the first researcher in one’s own writing and by referring to the earlier publication. Other than recognizing the work of different researchers, the citation process also helps readers discover the source article and refer to it to acquire more data or details.
The advent of the World Wide Web and the Internet has helped the process of identifying fitting, reliable, and logical scientific information and using it in one’s research with proper citations. The researcher takes recourse to online search tools, for example Google Scholar or PubMed, to gather information about publications revolving around the proposed research area. To disentangle the mass of search results, it is important to sieve research articles that could form part of the critical reading list.
Demonstrating In-Text Citing
The purpose of referencing or in-text citation is to give credit where it is expected. There are various reference style guides and it is up to the researcher and the requirements of the target journal to choose the most suitable one. If it’s a book citation, the author needs to consider the detailed referencing guidelines specific for books. In case of a thesis, the concerned university will have a favored reference style that needs to be followed. In case of research journals, one needs to visit the author page to peruse “Instruction for Authors.” Here, the author would get a bird’s-eye view of the required referencing style along with the in-text citation style. Once the reference style has been chosen, it is critical to remain faithful to the reference style in a consistent manner throughout the manuscript.
Here are three ways to use in-text research citations.
– Name-Year format: The surname of the first author is mentioned, followed by the publication year in brackets after the text.
For e.g.:
(Smith, 2017) or “Huron et al. (2017) stated that the tumor regeneration process was…”
– Citation-Sequence and Citation-Name: Both these citation styles are widely used by many journals. These two mainstream referencing styles are fundamentally the same. In both, in-text referencing is a number that compares to the full reference in the reference list. In case of Citation-Sequence, the number relates to every article’s ordered appearance. In case of Citation-Name format, the list of sources is arranged alphabetically. For example, if the primary article referenced in the manuscript was a work of Smith (an anonymous author name), this paper would be doled out the number 1. In the numbered book reference, if Citation-Sequence style is used, Smith would be the primary reference in the reference list. If Citation-Name style is used, the reference list would be arranged alphabetically, and the in-text number assigned to Smith would relate to whatever position Smith has in the reference list.
Hence, it is vital for a researcher or author to follow the reference style guide in an organized manner. Notably, footnotes are by and large not utilized as a part of logically written scientific work. Besides, there are style guides that demand abbreviating the journal names. For e.g.: International Journal of Civil Engineering can be abbreviated as ‎Int. J. Civ. Eng.
Fortunately, there are currently many reference management tools accessible to researchers and scientists. These tools assist academic research in maintaining consistency in reference citations with an assortment of style guides. Few examples are Mendeley, Zotero, EndNote, and Papers. These are additional reference directories, which are purchasable. However, all these reference managers also offer scholarly or understudy discounts.
Academic Publishing, Academic Research, Authors, Researchers

Sci-Hub – A New Napster for Academic Publishers

Sci-Hub or Scientific Hub is an open access online search engine that has gained popularity in the academic publishing industry in recent years. It is a repository of scholarly works with more than 58,000,000 published researches that are available for free and can be directly downloaded by the scholars.

How does it work?

Users can look up publications based on three search criteria: URL of the article, digital object identifier (DOI), and text search. The platform searches for the particular article in its library called Library Genesis (LibGen). If the platform is not able to locate the publication in LibGen, it tries to do so by using various institutional access systems. This can also enable access to articles published in the subscription mode by bypassing the paywall. These articles are usually donated by scholars or publishers.

Benefits of using Sci-Hub

This is a hub for not only research articles but other forms of research publications like monographs, books, book chapters, and so on. It offers free access to most of these researches and saves both money and time of the users. Sci-Hub shares similar goals as open access journals, making many scholarly publications available to anyone who searches for them. The site seeks to remove barriers to science through clear hints of piracy for those who cannot afford to pay the high subscription charges levied by journals or publication houses.

Sci-Hub has accomplished certain important breakthroughs. Its ambit covers many publications by scientists or researchers who have opted to publish in open access journals that can be accessed by anyone. In addition, it has brought academic publishing to the mainstream. As scientific credibility mostly depends on scientific publications, most of the chargeable journals own the copyright for their published articles. In this scenario, Sci-Hub helps researchers access these articles without any hidden cost.

Is the world of academia facing the gender disparity issue?

Gender-biased selection is a prominent concern in academics. This gender disparity is not only restricted to scientists and researchers, but also in evidence during the selection of peer reviewers.

Peer review is a vital process before acceptance of a paper in order to evaluate the research methods and validate the findings. It is conducted by subject experts and researchers of the concerned faculty. Despite having the same expertise and knowledge, male authors are preferred as peer reviewers over their female counterparts. Although nearly two-thirds of published authors in Australia are women, peer reviewers of two-thirds of the books are men. This disproportionate ratio has been valid for the last 30 years.

A recent analysis has revealed that most of the authors or scientists suggest male reviewers instead of female ones. Based on these recommendations, the journals also narrow down their list of peer reviewers by adding few male reviewers from their panel.  Eventually, the list comprises more male reviewers than their female counterparts that leads to gender disparity.

Being assigned as a peer reviewer is also considered as a networking tool for scientific collaborations; these reviewers seek out authors whose work they admire. Moreover, they also mention the journals that selected them to review papers in their resumes while applying for positions in faculties, research grants, and awards.

Brooks Hanson, an earth scientist and publication director at the American Geophysical Union in Washington, commented that peer reviewing is not only about the manuscript or author that are being examined, but the reviewers also get varied benefits from it. Besides, the reviewers get a chance to view the manuscripts instead of only reviewing the substantial and factual data. Consequently, the process turns out to be a learning session for the reviewer also.

Empirical data also supports the existence of gender-biased selections. In its annual report, the Australian international body of Vida showed the disparities between the writings of women and men in Britain and the US. In another survey in UK, women were found to be the buyers of two-thirds of the total books sold in Britain, and 50% of women consider themselves avid readers compared to 26% of men who felt similarly inclined. However, male authors are recorded to be winning more awards for their research, which are included in course syllabi at both high school and tertiary levels. In short, male authors are considered (erroneously) to be academically more talented than female authors.

The world of academics cannot afford such gender disparity in writing and research. Therefore, decision-makers are urged to encourage the academics fraternity by providing writers, reviewers, and readers an equal opportunity, irrespective of their gender, for a more wholesome future of the scientific and academic community.

Trump releases his 100 days plan- What for Science?

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Electing Donald Trump as the 45th American President will bring about scads of policy reforms, even faster than the people realize. Starting from freezing the employee recruitments to the scrapping of Obamacare initiatives are all on the list! In addition, the breakneck statements and views of Donald Trump on various scientific facts have also sparked strong reactions among academics. However, the term “Science” has turned out to be a jargon for the Republicans and has found no special mention in the 100 days plan. However, we will have a bird’s eye view on the Trump’s blueprint that he would gift the Americans and the world community this New Year, and figure out if the science facts have been addressed to.

Trump – Throwing on off Policy fetters
Trump’s hard-line positions on immigration — including his commitment towards barring Muslims or terror-prone nationals from entering the US, a plan for wall building across the Mexico borders, imbibing visa restrictions, prioritizing American workers, and the termination of job programs for foreign youths, have surely perturbed the research advocates. Such decisions could sidetrack many talented international students or researchers from studying or working at US institutions. The future of foreign research scholars in the USA could be jeopardized due to such visa restrictions.

Science Facts vs. Trump’s Contradiction- Will it affect R&D funding?
The US has been a major investor of federal dollars in the field of R&D. “The entire business of the US academic biomedical research enterprise is based on federal dollars. Without that, it would collapse,” says Ethan Weiss, an associate professor, University of California. Trump’s shockingly ignorant views on vaccination for children with autism, and calling climate change a hoax and data to be unrealistic, pulling out US (the second most carbon generator) from the Paris climate change submit), curtailing the funds to UN for supporting climate change initiatives, and calling NASA as a logistics agency, have surely put him under the scanner of the intellectuals.
As per the statement released in September, by Donald Trump, he says that “there are increasing demands to curtail spending and to balance the federal budget; we must make the commitment to invest in science, engineering, healthcare and other areas that will make the lives of Americans better, safer and more prosperous.” In an interview by sciencedebate.org, Trump added that “scientific advances do require long-term investment.” In spite of such speculations, the fate of R&D industry is too early to predict. However, before the commencement of 2017, the present US Congress Govt. could approve spending bills before Christmas. These bills will raise the National Institute of Health funding as well as the NSF budget. During the first year of Trump’s presidency, the public funding will be secured.

Uncertain change in the climate
Trump’s election could factor into climate negotiations and be a setback for the upcoming climate change meets. When the world is thinking of implementing Paris agreement, the exit of the US from the Paris summit can be an unfortunate development and the pledge of 800 million USD as the annual contribution to the United Nations Framework Convention on Climate Change may cease. However, legally Trump would not be able to sign off the Summit within his four years tenure.

Donald trump on Healthcare reforms
The Affordable Care Act, an initiative by Obama, which is in its current incarnation, won’t survive if Trump makes good on his campaign promises. By this logic, the funds linked to birth control programs would fade away, though not immediately. Trump may defund Obamacare and associated programs like state grant for medical care. A Trumpian shift to insurance premium deductions and insurance plans sales and the opening of tax-free Health Savings Accounts may not remedy the ultimate problem of high-cost health care services in the US.

Tech Boost and Trump
The Silicon Valley may be benefitted by the manufacturing revival initiative by Trump’s govt. “There are several things that a Trump administration could do that would be beneficial to tech,” says Rob Atkinson, president of the Information Technology and Innovation Foundation. The export industry will flourish over the import, which will be part and parcel of the shifting away from the traditional start-up model and the adjusted tax and trade policy.

We know very little
The research policies and development across a wide spectrum in the US political scenario are still up in the air and have kept the scientific community optimistic (though cautiously). The outcomes of Trump’s immigration policies are also not clear. This is considered as the central pillar of his campaign, which might or might not affect research. Leighton Ku, a professor at George Washington University, said that “it’s likely that the kinds of highly-skilled scientists who immigrate to the US for school or work would still be welcome. But will they want to come?” This is a billion dollar question that still remains unanswered.

Choosing a journal: Open access or traditional publication?

journal selection : Open access or traditional publication

What is open access publishing?

Open access (OA) publishing provides researchers and readers free access to research articles online. In case of OA journals, an article processing fee is levied on the authors after acceptance of the paper. This charge is payable by the researcher, author or the institution the author is affiliated to. However, certain OA journals do not charge any fee and support their operations through sponsorship or subscriptions of the journals.

What is traditional publishing?

Traditional publishing refers to a type of contract between the author and the publisher. In this type of publishing, the author receives a portion of the revenue generated from sales of the journals. This is also known as the “royalty payment model.”

Which route to adopt?

Various factors play a determining role for authors adopting either the open access or the traditional route for publication.

Many researchers consider the open access model as economically unsustainable because it imposes an additional financial burden on them as well as on the institute they are affiliated to. But again, it comes with a basket-full of advantages, such as a much quicker publication process compared to the traditional mode and enhanced visibility of the research to a broader audience. On the other hand, traditional publications have incorporated many reforms in their business models. They ensure manuscript quality and a brand value.

Many publishing houses place the onus on the author. They give authors the choice of either disseminating the research to a wide research community through an OA publication, or opting for the traditional mode of publication.

With the advent of the Internet, we are habituated to rapid changes in business models of the publication industry. However, the journal publication business has been relatively more resistant to change. That is a function of the prevailing academic culture, where the importance of a publication is recognized through the brand value of journals and their ability to promote the publication and win research grants.