Medicarpin, a potent bioactive compound found in plants like Sophora japonica and Glycyrrhiza species, exhibits diverse medicinal properties. Despite limited natural plant sources and low yields, this study identified eight key genes governing medicarpin biosynthesis. Through genetic engineering in Saccharomyces cerevisiae using liquiritigenin as a substrate, the team achieved medicarpin production at 0.82 ± 0.18 mg/L. Gene copy enhancements of vestitone reductase (VR) and pterocarpan synthase (PTS) boosted yields to 2.05 ± 0.72 mg/L. This research lays a robust foundation for economically viable and sustainable synthetic production of medicarpin via a synthetic biology approach.
Groundbreaking Discovery: Two new genes found in head and neck cancer patients responsible for chemotherapy resistance. Silencing these genes rekindles chemotherapy effectiveness, offering hope in cancer treatment.
One of the most crucial roles in the domain of manuscript publishing is that of the editor. While a manuscript undergoes a series of steps that finally leads to its publication in a journal of the author’s choice, editing is the first stage that breathes life into a raw document. An editor polishes the knowledge […]
History of the wonder drug “Thalidomide” In 1957, thalidomide was first marketed under the trade name Contergan in Germany. It is one of the most widely used immunotherapeutic agents to treat immune responses that involve suppression or induction of the immune system. It was prescribed as a sedative in cases of hypertension, sleeplessness or insomnia, […]