Selinexor, a novel inhibitor for multiple myeloma (MM), faces limited research on resistance. Heterogeneous nuclear ribonucleoprotein U (hnRNPU) was identified as a regulator impacting MM’s response to selinexor. Comparing control knockdown (CTR-KD) and hnRNPU knockdown (hnR-KD) MM cells revealed increased selinexor-induced cell death in hnR-KD cells in vitro and in mice. Lower hnRNPU expression correlated with positive patient response to selinexor. hnRNPU’s role involves influencing LTV1, NMD3 localization, and mRNA translation of MDM2 and RAN, key factors in XPO1-mediated nuclear export. These findings suggest hnRNPU could serve as a potential marker for categorizing MM patients for Selinexor use.
In an 18-month study of a Portuguese craft brewery, diastatic yeast contaminations were traced to environmental strains, distinct from the production yeast. Such contaminations, often unnoticed, were detected due to a specific PCR protocol. These contaminants, linked genetically to strains in Botswana, reveal the widespread and ecological presence of diastatic yeasts. Unlike Beer 1 strains, […]
Researchers at the University of Pittsburgh School of Medicine have created the first non-human primate model of hereditary Alzheimer’s in marmoset monkeys. The model is designed to accelerate the pace of drug discovery and rebuild the foundation for future translational studies. Marmoset families are better matched to mimic the genetically diverse human population than a […]
Lake Erie’s recreational beaches face persistent fecal contamination, impacting water quality and public health. Villa Angela and Headlands beaches in Ohio attract numerous visitors but encounter advisories due to high fecal indicator levels, primarily from gull droppings. Traditional methods assessing gull-related contamination, like gull counts or droppings, prove inadequate due to gulls’ dynamic behavior and […]