A recent Australasian study suggests that ketamine, commonly known as a recreational drug and anesthetic, could be beneficial for people with difficult-to-treat depression. The study involved administering ketamine injections to individuals with treatment-resistant depression, and positive results were observed. However, the long-term sustainability of these effects is still unknown. Ketamine is being explored as a potential treatment option for individuals who have not responded to at least two antidepressants. While ketamine shows promise, there are concerns about its potential for abuse. Other treatment options for treatment-resistant depression include transcranial magnetic stimulation, psilocybin, psychotherapy, and lifestyle changes. It is important for individuals to discuss available options with their healthcare provider.