Researchers at Imperial College London, in collaboration with Oxford Nanopore Technologies, have developed a new method combining nanopore sequencing and DNA barcoding for diagnosing diseases. Traditional blood tests typically focus on a limited number of biomarkers. This innovative approach allows the simultaneous analysis of dozens of biomarkers of various types from a single clinical sample. For instance, in a proof-of-concept study, the method detected 40 different types of miRNA molecules, expanding the scope of potential biomarkers. The test involves mixing blood samples with DNA barcodes and utilizing a handheld device, the MinION, to read electrical signatures from nanopores, providing a comprehensive profile for precise disease diagnosis. The adaptable nature of this method suggests broader applications in detecting various diseases, including cancer and neurodegenerative conditions. The researchers aim to validate the results with clinical samples from heart failure patients, paving the way for personalized and efficient diagnostic tools in the future. The study is published in Nature Nanotechnology.
Related Posts
TPGen: Pioneering Stable Protein Design with Targeted Topology
In protein engineering, achieving stable designs with specific topological structures is a critical pursuit. TPGen, a groundbreaking language model, emerges as a key player in this endeavor, offering a novel approach to precision protein design. This model uniquely focuses on stabilizing proteins through the deliberate control of their topology, promising advancements in various applications, from […]
Harnessing Machine Learning for Transparent Medical Insurance Cost Predictions
The opaque and unpredictable nature of medical insurance costs is a major source of stress and financial uncertainty for patients. Machine learning (ML) offers a promising avenue to revolutionize medical cost prediction, bringing transparency and empowerment to patients. Challenges of Medical Cost Prediction: Data silos: Medical data is often fragmented across hospitals, insurers, and labs, hindering comprehensive analysis. Complex […]
Algorithms unlock COVID-19 secrets: crafting smarter drugs for precision healing
Scientists are like detectives using computer programs to study tiny details of the COVID-19 virus. They want to make the medicine we use against the virus work even better. Imagine the virus as a tiny Lego set, and scientists are looking at each piece with a special tool. This helps them figure out how […]