Novel Halogenated Furanone Derivatives as Quorum Sensing Inhibitors

The overuse of antibiotics has led to multiple drug-resistant bacterial strains causing 16 million deaths annually. Bacterial biofilms, constituting 65% of infectious diseases, thrive via quorum sensing (QS). Inhibiting QS offers a promising strategy. Pseudomonas aeruginosa, a major nosocomial pathogen, employs AHLs (3OC12 and C4) for QS signaling, involving receptors QscR, LasR, and RhlR. Natural products, including sulfur compounds from garlic and halogenated furanones, show QS inhibitory potential. Focusing on furanone derivatives, a new series was designed from 2-furaldehyde, exploring 5-hydroxyl-3,4-halogenated-5H-furan-2-ones as potential inhibitors of biofilm formation.

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