Researchers at the University of Pittsburgh School of Medicine have created the first non-human primate model of hereditary Alzheimer’s in marmoset monkeys. The model is designed to accelerate the pace of drug discovery and rebuild the foundation for future translational studies. Marmoset families are better matched to mimic the genetically diverse human population than a colony of inbred rodents. And because marmosets’ life spans are shorter than those of other non-human primates, researchers can comprehensively study their aging within a relatively short period of time. The team is employing a battery of non-invasive tests, including behavioral studies, longitudinal analysis of blood biomarkers, and regular PET scans to assess brain function and pathological changes in the brain tissue. The researchers hope that this model will help them to better understand the underlying biological processes behind Alzheimer’s disease and develop new treatments for the condition.
Discovering the nuances of Cognitive Behavioral Therapy for Psychosis (CBTp). While it’s an established treatment, its impact varies. We’re delving into recent research, revealing that factors like the therapeutic alliance and targeting underlying psychological mechanisms can enhance outcomes. It’s clear that personalized CBTp is the way forward, just as in anxiety and depression treatment. Let’s […]
When a manuscript is submitted to a journal, it undergoes a thorough quality check under the peer review process before being sent to the chief editor. Most articles face rejection during this process. There are several reasons for this. 1. The article is beyond the scope of the journal Your article can be immediately rejected […]
A new tutorial published in the journal Nature Methods provides a comprehensive overview and comparison of 23 publicly available computational tools for predicting intrinsic disorder in proteins. The guide includes information on accuracy, runtime, availability, and the need for functional insights. It also provides examples and instructions for using the selected tools, as well as […]