Histidine methylation, a new post-translational modification, is not well understood. A recent study identified γ-enolase, a glycolytic enzyme subunit, as a new substrate for histidine methylation. The study found that methylation of the 190th histidine residue of γ-enolase is important for subunit dimerization and enolase activity. None of the three previously identified mammalian histidine methyltransferases catalyzed the methylation of γ-enolase. These results suggest that γ-enolase is a unique research tool for exploring new histidine methyltransferases.
