Histidine methylation, a new post-translational modification, is not well understood. A recent study identified γ-enolase, a glycolytic enzyme subunit, as a new substrate for histidine methylation. The study found that methylation of the 190th histidine residue of γ-enolase is important for subunit dimerization and enolase activity. None of the three previously identified mammalian histidine methyltransferases catalyzed the methylation of γ-enolase. These results suggest that γ-enolase is a unique research tool for exploring new histidine methyltransferases.
The field of biomedicine stands on the precipice of a transformative era, where AI-powered algorithms hold the promise of revolutionizing disease diagnosis, patient outcome prediction, and personalized medicine. However, this potential hinges on a fundamental prerequisite: data provenance. Think of data provenance as the meticulous detective work of the digital realm. It involves meticulously recording […]
Deep within your cells lies a hidden world of miniature power plants, tirelessly generating energy to fuel your body’s every function. These powerhouses, known as mitochondria, play a critical role in maintaining health, but their malfunctions can pave the way for disease. Until recently, investigating these “mitochondrial glitches” required invasive tissue biopsies. But a groundbreaking […]
Introduction: Essential thrombocytosis (ET) is a chronic blood disorder characterized by an abnormally high platelet count. This can increase the risk of both thrombosis (blood clots) and hemorrhage (bleeding). Thrombocytapheresıs is a procedure that removes platelets from the blood, and it is sometimes used to treat ET patients who are experiencing acute thrombotic or […]