Chloroquine with TB antibiotic may reduce drug resistance

A research conducted by scientists at the Indian Institute of Science and Tata Institute of Fundamental Research found that administering anti-malarial drug Chloroquine with anti-TB drugs can reduce the tolerance of TB bacteria towards it. That, in turn, can help fight drug-resistant TB. In their work, the researchers noted that one of the things that make fighting TB so difficult is that the bacteria are able to increase the acidity in the area where they reside. So the researchers gave patients chloroquine to reduce acidity, along with another drug to sneak in and take out the TB bacteria. The researchers report that their idea worked in both mice and guinea pigs, reducing treatment time to just eight weeks.

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