Diabetic Mice Improve With Retrievable Millimetre-thick Cell-laden Hydro-gel Fiber

There has been a recent advancement in the treatment of Type 1 Diabetes as the researchers at the Institute of Industrial Science, The University of Tokyo) found out that the diameter of hydrogels carrying cells can establish its longevity after transplantation, making the cell therapy for Type 1Diabetes Mellitus efficient. In short, researchers have come up with a fiber shaped hydrogel transplant that can be successful at treating T1DM.

Type 1 Diabetes, also known as insulin-dependent diabetes, is becoming an increasingly common disease among young and adults alike. A 2017 report revealed that about 425 million adults in the age group of 20-79 were living with diabetes around the world. The cause of Type 1Diabetes Mellitus is autoimmune destruction of -βcells that are responsible for producing insulin which is an important hormone that facilitates sugar flow in the cells to produce energy.

At the moment, the treatment for T1DM involves timed exogenous insulin administration and continuous blood glucose measurements. This creates an unnecessary burden not only on the patient but also on the health system. The aim of the new cell therapy is to eliminate the need for insulin replacement as it focuses on substituting lost pancreaticβ-cells. Although cell replacement therapy appears to be an interesting option, its clinical success is quite limited. It is often compared to an organ transplant that depends highly on the transplant -acceptance. Foreign body reactions are common factors behind transplant rejection. The idea behind cell therapy is to make use of hydrogels to provide long-term protection for transplanted cells.

This is not the only research that focuses on the replacement of damaged cells to cure this auto-immune disorder, the whole pancreas transplant has already been successful at many clinics. It was noted that even though blood sugar levels were immediately restored following the transplant, the survival rate of the transplanted pancreas was as low as six months. This improved over the years with the advancement of technology but even at present, the transplant doesn’t survive for more than three years.

Interestingly, the study conducted by the researchers at the University of Tokyo revealed that the diameter of these hydrogel fibers can be detrimental in anticipating foreign body reactions. The tests were conducted on diabetic mice. Barium alginate (Ba-Alg) hydrogels with different fiber diameters were implanted into normal mice. This was done to demonstrate that immune reactions seemed quite low at 1.0 mm. In order to further concretize the claim, researchers compared these findings with the foreign body reactions at 0.35 mm. The results revealed that covering hydrogel in 1.0mm-thick fibers resulted in long-term immune-protection for islets of Langerhans and also helped maintain glycemic control in diabetic mice. These fibers also facilitated the easy flow of small molecules of glucose, insulin, and oxygen to pass through the membrane, which is crucial for better functioning of the cells.

The findings definitely give hope, and more clinical trials could be helpful in repairing all possible loopholes.

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