Chinese scientists have developed a simplified technique to create DNA-based programmable gate arrays (DPGAs), versatile computing units. Previous DPGAs were complex, hindering production. This new method combines DNA origami and chemical reactions to simplify design and produce DPGAs with numerous gates. They successfully created a DPGA with 24 gates, programmable for over 100 billion circuits. Cascading three DPGAs solved quadratic equations, and integrating one with an analog-to-digital converter classified microRNAs. This innovation holds promise for advancing DNA-based computing devices across various applications.