A new study from Northwestern Medicine challenges a common belief in what triggers Parkinson’s disease. The study suggests that a dysfunction in the neuron’s synapses — the tiny gap across which a neuron can send an impulse to another neuron — leads to deficits in dopamine and precedes neurodegeneration. This finding opens up a new avenue for therapies, as it suggests that targeting dysfunctional synapses, before the neurons are degenerated, may represent a better therapeutic strategy.
A new machine learning approach developed by researchers at MIT and Harvard University could help scientists more efficiently design experiments to engineer cells into new states. This could have a significant impact on the development of new therapies for cancer, regenerative medicine, and other diseases. The new approach leverages the cause-and-effect relationship between factors in […]
Scientists have created a new platform using zebrafish “avatars” to screen for novel treatments for glioblastoma, an aggressive brain tumor. This platform could also be used to predict whether a particular patient will respond to a therapy. The researchers injected glioblastoma stem cells from seven patients into zebrafish embryos, creating xenograft models for each patient. […]
Researchers have developed a new self-supervised learning method that can improve the training of genomic models with less labeled data. The method, called Self-GenomeNet, leverages reverse-complement sequences and effectively learns short- and long-term dependencies by predicting targets of different lengths. Self-GenomeNet outperforms other self-supervised methods in data-scarce genomic tasks and outperforms standard supervised training with […]